The Institutional Review Entity (IRE) reviews any research or work conducted at, or on behalf of the University of Virginia that involves one of the 15 agents or toxins* and any categories of experiments designated as Dual Use Research of Concern (DURC) by the United States Government Policy for Institutional Oversight of Life Sciences Dual Use Research of Concern or DURC.

DURC is life sciences research that, based on current understanding, can be reasonably anticipated to provide knowledge, information, products, or technologies that could be directly misapplied to pose a significant threat with broad potential consequences to public health and safety, agricultural crops and other plants, animals, the environment, material, or national security.

IRE Charge

Mission

The IRE will ensure that all research involving the acquisition, use, handling storage and disposal of DURC materials is reviewed for DURC potential. Furthermore, the committee is responsible for reviewing all proposed research subject to DURC conducted by faculty, staff, students and/or visiting scientists, creating draft mitigation plans when required, and submitting these plans to the United States Government (USG) agency funding the proposed research. If the research is non-Federally funded the plan is submitted to NIH for review or referral. The IRE will also annually review active mitigation plans, and report any changes in DURC or mitigations plans to the appropriate USG agency within 30 days.

*DURC research applies to the following agents and categories of experiments:

  • Agents:
    1. Avian influenza virus (highly pathogenic)
    2. Bacillus anthracis
    3. Botulinum neurotoxin (note: there are no exempt quantities of botulinum neurotoxin. Research involving any quantity of botulinum neurotoxin is included.)
    4. Burkholderia mallei
    5. Burkholderia pseudomallei
    6. Ebola virus (BSL4)
    7. Foot-and-mouth disease virus
    8. Francisella tularensis
    9. Marburg virus (BSL4)
    10. Reconstructed 1918 Influenza virus
    11. Rinderpest virus
    12. Toxin-producing strains of Clostridium botulinum
    13. Variola major virus (BSL4)
    14. Variola minor virus
    15. Yersinia pestis
  • Categories of experiments:
    1. Enhance the harmful consequences of a biological agent or toxin
    2. Disrupt immunity or effectiveness of an immunization against a biological agent or toxin without clinical or agricultural justification
    3. Confer to a biological agent or toxin resistance to clinically and/or agriculturally useful prophylactic or therapeutic interventions against that agent or toxin or facilitate their ability to evade detection methodologies
    4. Increase the stability, transmissibility, or the ability to disseminate the agent or toxin;
    5. Alter the host range or tropism of the agent or toxin
    6. Enhance the susceptibility of a host population to a biological agent or toxin
    7. Generation of a novel pathogenic agent, or reconstitution of an eradicated or extinct biological agent

IRE Meeting Schedule

If you would like to attend a meeting, please contact Paul Skoglund at ps5d@virginia.edu or 434-243-0726, by the date the Registration Documents are due.

Date of IRE Meeting Date Registration (Progress reports) Documents are due Location Time
November 5th, 2019 October 24th, 2019 MR6, room 2501 8:30am
December 3rd, 2019 November 19th, 2019 MR6, room 2501 8:30am
January 7th, 2020 December 18th, 2019 MR6, room 2501 8:30am
February 4th, 2020 January 23rd, 2020 MR6, room 2501 8:30am
March 3rd, 2020 February 20th, 2020 MR6, room 2501 8:30am
April 7th, 2020 March 26th, 2020 MR6, room 2501 8:30am
May 5th, 2020 April 23rd, 2020 MR6, room 2501 8:30am
June 2nd, 2020 May 21st, 2020 MR6, room 2501 8:30am
July 7th, 2020 June 25th, 2020 MR6, room 2501 8:30am
August 4th, 2020 July 23rd, 2020 MR6, room 2501 8:30am
September 1st, 2020 August 20th, 2020 MR6, room 2501 8:30am
October 6th, 2020 September 24th, 2020 MR6, room 2501 8:30am
November 3rd, 2020 October 22nd, 2020 MR6, room 2501 8:30am
December 1st, 2020 November 19th, 2020 MR6, room 2501 8:30am
January 5th, 2021 December 21st, 2020 MR6, room 2501 8:30am

IRE Members

Prof. Barbara J. Mann
IRE Chair
Associate Professor
Department of Medicine, Infectious Diseases
434-924-9666

Jennifer Branum
UVA Biosafety Officer
Alternate Responsible Official (Select Agents)
434-982-4911

Marie Burdick
IRE Member
Principal Scientist
Department of Medicine, Pulmonary and Critical Care
434-243-7363

Sanford Feldman
IRE Member
Director of the Center for Comparative Medicine
434-924-5058

Glynis L. Kolling
IRE Member
Assistant Professor of Medicine
Department of Biomedical Engineering
434-924-5630

Tom Leonard
IRE Member
Responsible Official (Select Agents)
EHS Director
434-982-4911

Prof. Aaron L. Mills
IRE Member
Professor
Department of Environmental Sciences
434-924-0564

Prof. Ira Schulman
IRE Member
Associate Professor
Department of Pharmacology
434-924-5682

Prof. Scott Vande Pol
IRE Member
Associate Professor
Department of Pathology
434-924-1603

Paul Skoglund
IRE Coordinator
434-243-0726

 
 
Special Materials Handling Facility
515 Edgemont Road
P.O. Box 400322
Charlottesville, VA 22904-4322
PHONE 434.982.4911
FAX 434.982.4915
One Morton Drive
Suite 320
P.O. Box 400333
Charlottesville, VA 22904-4333
FAX 434.243.1735
EMAIL vck9u@virginia.edu
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